Abstract
Background
There is substantial symptom overlap in psychosis and autism spectrum disorder (ASD) and co-morbidity is common. In addition, antipsychotic response may be moderated by the co-occurrence. Individuals with ASD may be at greater risk of some clozapine adverse effects and occasionally, its use may be contra-indicated.
Case presentation
We present the case of a patient with ASD with psychosis unresponsive to multiple antipsychotics, but extra precaution was required with clozapine.
Conclusion
A multidisciplinary approach is required to establish clozapine in a patient with schizophrenia and ASD
There is substantial symptom overlap in psychosis and autism spectrum disorder (ASD) and co-morbidity is common. In addition, antipsychotic response may be moderated by the co-occurrence. Individuals with ASD may be at greater risk of some clozapine adverse effects and occasionally, its use may be contra-indicated.
Case presentation
We present the case of a patient with ASD with psychosis unresponsive to multiple antipsychotics, but extra precaution was required with clozapine.
Conclusion
A multidisciplinary approach is required to establish clozapine in a patient with schizophrenia and ASD
| Original language | English |
|---|---|
| Article number | 1158 |
| Journal | BMC Psychiatry |
| Volume | 25 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 25 Nov 2025 |
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