Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes

Zhen Ping; Si Chen; Sjoerd J.F. Hermans; Keane J.G. Kenswil; Jacqueline Feyen; Claire van Dijk; Eric M.J. Bindels; Athina M. Mylona; Niken M. Adisty; Remco M. Hoogenboezem; Mathijs A. Sanders; Eline M.P. Cremers; Dicky J. Lindenbergh-Kortleve; Janneke N. Samsom; Arjan A. van de Loosdrecht; Marc H.G.P. Raaijmakers

doi:10.1038/s41375-018-0267-x

Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes

Zhen Ping
, Si Chen
, Sjoerd J.F. Hermans
, Keane J.G. Kenswil
, Jacqueline Feyen
, Claire van Dijk
, Eric M.J. Bindels
, Athina M. Mylona
, Niken M. Adisty
, Remco M. Hoogenboezem
, Mathijs A. Sanders
, Eline M.P. Cremers
, Dicky J. Lindenbergh-Kortleve
, Janneke N. Samsom
, Arjan A. van de Loosdrecht
, Marc H.G.P. Raaijmakers

Erasmus University Rotterdam
Department of Hematology
VU University Medical Center

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS.Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis.Activation of NF-κB attenuates HSPC numbers and function ex vivo.

Original language	English
Pages (from-to)	536-541
Number of pages	6
Journal	Leukemia
Volume	33
Issue number	2
DOIs	https://doi.org/10.1038/s41375-018-0267-x
Publication status	Published - 1 Feb 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Mesenchymal cells
Hematopoiesis
Low-risk myelodysplastic syndromes
Leukemia

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10.1038/s41375-018-0267-xLicence: CC BY

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Ping, Z., Chen, S., Hermans, S. J. F., Kenswil, K. J. G., Feyen, J., van Dijk, C., Bindels, E. M. J., Mylona, A. M., Adisty, N. M., Hoogenboezem, R. M., Sanders, M. A., Cremers, E. M. P., Lindenbergh-Kortleve, D. J., Samsom, J. N., van de Loosdrecht, A. A., & Raaijmakers, M. H. G. P. (2019). Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes. Leukemia, 33(2), 536-541. https://doi.org/10.1038/s41375-018-0267-x

@article{5a2e315e0d4a4d55a6e8f96c1e5a7129,

title = "Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes",

abstract = "Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS.Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis.Activation of NF-κB attenuates HSPC numbers and function ex vivo.",

keywords = "Mesenchymal cells, Hematopoiesis, Low-risk myelodysplastic syndromes, Leukemia",

author = "Zhen Ping and Si Chen and Hermans, \{Sjoerd J.F.\} and Kenswil, \{Keane J.G.\} and Jacqueline Feyen and \{van Dijk\}, Claire and Bindels, \{Eric M.J.\} and Mylona, \{Athina M.\} and Adisty, \{Niken M.\} and Hoogenboezem, \{Remco M.\} and Sanders, \{Mathijs A.\} and Cremers, \{Eline M.P.\} and Lindenbergh-Kortleve, \{Dicky J.\} and Samsom, \{Janneke N.\} and \{van de Loosdrecht\}, \{Arjan A.\} and Raaijmakers, \{Marc H.G.P.\}",

note = "Publisher Copyright: {\textcopyright} 2018, The Author(s).",

year = "2019",

month = feb,

day = "1",

doi = "10.1038/s41375-018-0267-x",

language = "English",

volume = "33",

pages = "536--541",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Springer Nature",

number = "2",

}

Ping, Z, Chen, S, Hermans, SJF, Kenswil, KJG, Feyen, J, van Dijk, C, Bindels, EMJ, Mylona, AM, Adisty, NM, Hoogenboezem, RM, Sanders, MA, Cremers, EMP, Lindenbergh-Kortleve, DJ, Samsom, JN, van de Loosdrecht, AA & Raaijmakers, MHGP 2019, 'Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes', Leukemia, vol. 33, no. 2, pp. 536-541. https://doi.org/10.1038/s41375-018-0267-x

TY - JOUR

T1 - Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes

AU - Ping, Zhen

AU - Chen, Si

AU - Hermans, Sjoerd J.F.

AU - Kenswil, Keane J.G.

AU - Feyen, Jacqueline

AU - van Dijk, Claire

AU - Bindels, Eric M.J.

AU - Mylona, Athina M.

AU - Adisty, Niken M.

AU - Hoogenboezem, Remco M.

AU - Sanders, Mathijs A.

AU - Cremers, Eline M.P.

AU - Lindenbergh-Kortleve, Dicky J.

AU - Samsom, Janneke N.

AU - van de Loosdrecht, Arjan A.

AU - Raaijmakers, Marc H.G.P.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS.Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis.Activation of NF-κB attenuates HSPC numbers and function ex vivo.

AB - Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS.Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis.Activation of NF-κB attenuates HSPC numbers and function ex vivo.

KW - Mesenchymal cells

KW - Hematopoiesis

KW - Low-risk myelodysplastic syndromes

KW - Leukemia

UR - https://www.scopus.com/pages/publications/85054740827

U2 - 10.1038/s41375-018-0267-x

DO - 10.1038/s41375-018-0267-x

M3 - Article

C2 - 30315231

AN - SCOPUS:85054740827

SN - 0887-6924

VL - 33

SP - 536

EP - 541

JO - Leukemia

JF - Leukemia

IS - 2

ER -

Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes

Abstract

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Keywords

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