Cell therapy for osteonecrosis of femoral head and joint preservation

Anan Shetty

doi:10.1016/j.jcot.2021.101713

Cell therapy for osteonecrosis of femoral head and joint preservation

Anan Shetty

Research output: Contribution to journal › Article › peer-review

Abstract

Osteonecrosis of femoral head (ONFH) is a disease of the femoral head and can cause femoral head collapse and arthritis. This can lead to pain and gait disorders. ONFH has various risk factors, it is often progressive, and if untreated results in secondary osteo-arthritis. Biological therapy makes use of bone marrow concentrate, cultured osteoblast and mesenchymal stem cell (MSC) obtained from various sources. These are often used in conjunction with core decompression surgery. In this review article, we discuss the current status of cell therapy and its limitations. We also present the future development of biological approach to treat ONFH. [Abstract copyright: © 2021.]

Original language	English
Pages (from-to)	101713
Journal	Journal of Clinical Orthopaedics and Trauma
Volume	24
DOIs	https://doi.org/10.1016/j.jcot.2021.101713 https://doi.org/S0976-5662(21)00597-X
Publication status	Published - 27 Nov 2021

Keywords

Cell therapy
Core decompression
Femoral head
Osteonecrosis
Pathogenesis
Stem cell

Access to Document

Cite this

@article{97ca26e842e84eb7a8857beba25de2f1,

title = "Cell therapy for osteonecrosis of femoral head and joint preservation",

abstract = "Osteonecrosis of femoral head (ONFH) is a disease of the femoral head and can cause femoral head collapse and arthritis. This can lead to pain and gait disorders. ONFH has various risk factors, it is often progressive, and if untreated results in secondary osteo-arthritis. Biological therapy makes use of bone marrow concentrate, cultured osteoblast and mesenchymal stem cell (MSC) obtained from various sources. These are often used in conjunction with core decompression surgery. In this review article, we discuss the current status of cell therapy and its limitations. We also present the future development of biological approach to treat ONFH. [Abstract copyright: {\textcopyright} 2021.]",

keywords = "Cell therapy, Core decompression, Femoral head, Osteonecrosis, Pathogenesis, Stem cell",

author = "Anan Shetty",

year = "2021",

month = nov,

day = "27",

doi = "10.1016/j.jcot.2021.101713",

language = "English",

volume = "24",

pages = "101713",

journal = "Journal of Clinical Orthopaedics and Trauma",

issn = "0976-5662",

publisher = "Delhi Orthopedic Association",

}

TY - JOUR

T1 - Cell therapy for osteonecrosis of femoral head and joint preservation

AU - Shetty, Anan

PY - 2021/11/27

Y1 - 2021/11/27

N2 - Osteonecrosis of femoral head (ONFH) is a disease of the femoral head and can cause femoral head collapse and arthritis. This can lead to pain and gait disorders. ONFH has various risk factors, it is often progressive, and if untreated results in secondary osteo-arthritis. Biological therapy makes use of bone marrow concentrate, cultured osteoblast and mesenchymal stem cell (MSC) obtained from various sources. These are often used in conjunction with core decompression surgery. In this review article, we discuss the current status of cell therapy and its limitations. We also present the future development of biological approach to treat ONFH. [Abstract copyright: © 2021.]

AB - Osteonecrosis of femoral head (ONFH) is a disease of the femoral head and can cause femoral head collapse and arthritis. This can lead to pain and gait disorders. ONFH has various risk factors, it is often progressive, and if untreated results in secondary osteo-arthritis. Biological therapy makes use of bone marrow concentrate, cultured osteoblast and mesenchymal stem cell (MSC) obtained from various sources. These are often used in conjunction with core decompression surgery. In this review article, we discuss the current status of cell therapy and its limitations. We also present the future development of biological approach to treat ONFH. [Abstract copyright: © 2021.]

KW - Cell therapy

KW - Core decompression

KW - Femoral head

KW - Osteonecrosis

KW - Pathogenesis

KW - Stem cell

U2 - 10.1016/j.jcot.2021.101713

DO - 10.1016/j.jcot.2021.101713

M3 - Article

SN - 0976-5662

VL - 24

SP - 101713

JO - Journal of Clinical Orthopaedics and Trauma

JF - Journal of Clinical Orthopaedics and Trauma

ER -

Cell therapy for osteonecrosis of femoral head and joint preservation

Abstract

Keywords

Access to Document

Fingerprint

Cite this