Characterisation of the reaction mechanism between ammonia and formaldehyde from the topological analysis of ELF and catastrophe theory perspective

A prototypical reaction between ammonia and
formaldehyde has been investigated at the DFT(M06)/6-
311++G(d,p) computational level using the Bonding
Evolution Theory (BET). BET is a very useful tool for studying reaction mechanisms as it combines topological analysis of electron localisation function with the catastrophe theory.

Each of two studied reactions: H2C=O + NH3 ↔ HO–C(H2)–
NH2 (hemiaminal) and HO–C(H2)–NH2 ↔ HN = CH2 (Schiff
base) + H2O consists of six steps. Formation of hemiaminal
starts from a nucleophillic attack of nitrogen lone pair in NH3 on the carbon atom in H2C=O and is subsequently followed
by hydrogen transfer within the N–H..O bridge. A Schiff base
is formed via the dehydration reaction of the hemiaminal,
where the C–O bond is broken first, followed by hydrogen
transfer towards the [HO]δ− moiety, resulting in water and
methanimine. The present paper focuses on differences in reaction mechanisms for the processes described above. The
results have been compared to the reaction mechanism for
stable hemiaminal synthesis from benzaldehyde and 4-
amine-4H-1,2,4-triazole studied previously using the BET
theory