Disentangling the Gordian Knot of parasympathetic innervations in arthritic joint

Stergios Boussios

doi:10.1016/j.neuroscience.2025.03.061

Disentangling the Gordian Knot of parasympathetic innervations in arthritic joint

Stergios Boussios

Research output: Contribution to journal › Article › peer-review

Abstract

Healthy synovial joints receive innervations exclusively from sensory and sympathetic axons. In arthritis, however, they acquire cholinergic innervations with parasympathetic effects. The origin of cholinergic fibres in inflamed joints remains elusive. Based on clinical and preclinical evidence, we propose two models explaining their rise: (1) through sprouting and invasion of cholinergic sympathetic or parasympathetic axons from the periosteum of juxta-articular bones and (2) via phenotypic switch of intrinsic sympathetic (norepinephrinergic) fibres of synovial joints to cholinergic. The widely acknowledged anti-inflammatory and immunosuppressants effects of parasympathetic drive suggests a protective role of the newly aquired cholinergic innervations in arthritic joints. [Abstract copyright: Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved.]

Original language	English
Pages (from-to)	518-520
Journal	Neuroscience
Volume	573
DOIs	https://doi.org/10.1016/j.neuroscience.2025.03.061
Publication status	Published - 1 Apr 2025

Keywords

Arthritis
Cholinergic profiles
Neural remodelling
Parasympathetic system
Synovial joints

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title = "Disentangling the Gordian Knot of parasympathetic innervations in arthritic joint",

abstract = "Healthy synovial joints receive innervations exclusively from sensory and sympathetic axons. In arthritis, however, they acquire cholinergic innervations with parasympathetic effects. The origin of cholinergic fibres in inflamed joints remains elusive. Based on clinical and preclinical evidence, we propose two models explaining their rise: (1) through sprouting and invasion of cholinergic sympathetic or parasympathetic axons from the periosteum of juxta-articular bones and (2) via phenotypic switch of intrinsic sympathetic (norepinephrinergic) fibres of synovial joints to cholinergic. The widely acknowledged anti-inflammatory and immunosuppressants effects of parasympathetic drive suggests a protective role of the newly aquired cholinergic innervations in arthritic joints. [Abstract copyright: Copyright {\textcopyright} 2025 The Author(s). Published by Elsevier Inc. All rights reserved.]",

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AU - Boussios, Stergios

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N2 - Healthy synovial joints receive innervations exclusively from sensory and sympathetic axons. In arthritis, however, they acquire cholinergic innervations with parasympathetic effects. The origin of cholinergic fibres in inflamed joints remains elusive. Based on clinical and preclinical evidence, we propose two models explaining their rise: (1) through sprouting and invasion of cholinergic sympathetic or parasympathetic axons from the periosteum of juxta-articular bones and (2) via phenotypic switch of intrinsic sympathetic (norepinephrinergic) fibres of synovial joints to cholinergic. The widely acknowledged anti-inflammatory and immunosuppressants effects of parasympathetic drive suggests a protective role of the newly aquired cholinergic innervations in arthritic joints. [Abstract copyright: Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved.]

AB - Healthy synovial joints receive innervations exclusively from sensory and sympathetic axons. In arthritis, however, they acquire cholinergic innervations with parasympathetic effects. The origin of cholinergic fibres in inflamed joints remains elusive. Based on clinical and preclinical evidence, we propose two models explaining their rise: (1) through sprouting and invasion of cholinergic sympathetic or parasympathetic axons from the periosteum of juxta-articular bones and (2) via phenotypic switch of intrinsic sympathetic (norepinephrinergic) fibres of synovial joints to cholinergic. The widely acknowledged anti-inflammatory and immunosuppressants effects of parasympathetic drive suggests a protective role of the newly aquired cholinergic innervations in arthritic joints. [Abstract copyright: Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved.]

KW - Arthritis

KW - Cholinergic profiles

KW - Neural remodelling

KW - Parasympathetic system

KW - Synovial joints

U2 - 10.1016/j.neuroscience.2025.03.061

DO - 10.1016/j.neuroscience.2025.03.061

M3 - Article

SN - 0306-4522

VL - 573

SP - 518

EP - 520

JO - Neuroscience

JF - Neuroscience

ER -

Disentangling the Gordian Knot of parasympathetic innervations in arthritic joint

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Keywords

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