Reactive community-based self-administered treatment against residual malaria transmission: study protocol for a randomized controlled trial

Joseph Okebe; Joan Muela Ribera; Julie Balen; Fatou Jaiteh; Yoriko Masunaga; Davis Nwakanma; John Bradley; Shunmay Yeung; Koen Peeters Grietens; Umberto D'Alessandro

doi:10.1186/s13063-018-2506-x

Reactive community-based self-administered treatment against residual malaria transmission: study protocol for a randomized controlled trial

Joseph Okebe
, Joan Muela Ribera
, Julie Balen
, Fatou Jaiteh
, Yoriko Masunaga
, Davis Nwakanma
, John Bradley
, Shunmay Yeung
, Koen Peeters Grietens
, Umberto D'Alessandro

Disease Control & Elimination Theme
Medial Anthropology Research Center (MARC)
School of Health and Related Research-ScHARR
The University of Sheffield
Institute of Tropical Medicine Antwerp
London School of Hygiene and Tropical Medicine

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

BACKGROUND: Systematic treatment of all individuals living in the same compound of a clinical malaria case may clear asymptomatic infections and possibly reduce malaria transmission, where this is focal. High and sustained coverage is extremely important and requires active community engagement. This study explores a community-based approach to treating malaria case contacts.

METHODS/DESIGN: This is a cluster-randomized trial to determine whether, in low-transmission areas, treating individuals living in the same compound of a clinical malaria case with dihydroartemisinin-piperaquine can reduce parasite carriage and thus residual malaria transmission. Treatment will be administered through the local health system with the approach of encouraging community participation designed and monitored through formative research. The trial goal is to show that this approach can reduce in intervention villages the prevalence of Plasmodium falciparum infection toward the end of the malaria transmission season.

DISCUSSION: Adherence and cooperation of the local communities are critical for the success of mass treatment campaigns aimed at reducing malaria transmission. By exploring community perceptions of the changing trends in malaria burden, existing health systems, and reaction to self-administered treatment, this study will develop and adapt a model for community engagement toward malaria elimination that is cost-effective and fits within the existing health system.

TRIAL REGISTRATION: Clinical trials.gov, NCT02878200 . Registered on 25 August 2016.

Original language	English
Pages (from-to)	126
Journal	Trials
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s13063-018-2506-x
Publication status	Published - 20 Feb 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antimalarials/administration & dosage
Community Health Services
Data Analysis
Data Collection
Humans
Malaria, Falciparum/drug therapy
Randomized Controlled Trials as Topic
Self Administration

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10.1186/s13063-018-2506-x

Cite this

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abstract = "BACKGROUND: Systematic treatment of all individuals living in the same compound of a clinical malaria case may clear asymptomatic infections and possibly reduce malaria transmission, where this is focal. High and sustained coverage is extremely important and requires active community engagement. This study explores a community-based approach to treating malaria case contacts.METHODS/DESIGN: This is a cluster-randomized trial to determine whether, in low-transmission areas, treating individuals living in the same compound of a clinical malaria case with dihydroartemisinin-piperaquine can reduce parasite carriage and thus residual malaria transmission. Treatment will be administered through the local health system with the approach of encouraging community participation designed and monitored through formative research. The trial goal is to show that this approach can reduce in intervention villages the prevalence of Plasmodium falciparum infection toward the end of the malaria transmission season.DISCUSSION: Adherence and cooperation of the local communities are critical for the success of mass treatment campaigns aimed at reducing malaria transmission. By exploring community perceptions of the changing trends in malaria burden, existing health systems, and reaction to self-administered treatment, this study will develop and adapt a model for community engagement toward malaria elimination that is cost-effective and fits within the existing health system.TRIAL REGISTRATION: Clinical trials.gov, NCT02878200 . Registered on 25 August 2016.",

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T2 - study protocol for a randomized controlled trial

AU - Okebe, Joseph

AU - Ribera, Joan Muela

AU - Balen, Julie

AU - Jaiteh, Fatou

AU - Masunaga, Yoriko

AU - Nwakanma, Davis

AU - Bradley, John

AU - Yeung, Shunmay

AU - Peeters Grietens, Koen

AU - D'Alessandro, Umberto

PY - 2018/2/20

Y1 - 2018/2/20

N2 - BACKGROUND: Systematic treatment of all individuals living in the same compound of a clinical malaria case may clear asymptomatic infections and possibly reduce malaria transmission, where this is focal. High and sustained coverage is extremely important and requires active community engagement. This study explores a community-based approach to treating malaria case contacts.METHODS/DESIGN: This is a cluster-randomized trial to determine whether, in low-transmission areas, treating individuals living in the same compound of a clinical malaria case with dihydroartemisinin-piperaquine can reduce parasite carriage and thus residual malaria transmission. Treatment will be administered through the local health system with the approach of encouraging community participation designed and monitored through formative research. The trial goal is to show that this approach can reduce in intervention villages the prevalence of Plasmodium falciparum infection toward the end of the malaria transmission season.DISCUSSION: Adherence and cooperation of the local communities are critical for the success of mass treatment campaigns aimed at reducing malaria transmission. By exploring community perceptions of the changing trends in malaria burden, existing health systems, and reaction to self-administered treatment, this study will develop and adapt a model for community engagement toward malaria elimination that is cost-effective and fits within the existing health system.TRIAL REGISTRATION: Clinical trials.gov, NCT02878200 . Registered on 25 August 2016.

AB - BACKGROUND: Systematic treatment of all individuals living in the same compound of a clinical malaria case may clear asymptomatic infections and possibly reduce malaria transmission, where this is focal. High and sustained coverage is extremely important and requires active community engagement. This study explores a community-based approach to treating malaria case contacts.METHODS/DESIGN: This is a cluster-randomized trial to determine whether, in low-transmission areas, treating individuals living in the same compound of a clinical malaria case with dihydroartemisinin-piperaquine can reduce parasite carriage and thus residual malaria transmission. Treatment will be administered through the local health system with the approach of encouraging community participation designed and monitored through formative research. The trial goal is to show that this approach can reduce in intervention villages the prevalence of Plasmodium falciparum infection toward the end of the malaria transmission season.DISCUSSION: Adherence and cooperation of the local communities are critical for the success of mass treatment campaigns aimed at reducing malaria transmission. By exploring community perceptions of the changing trends in malaria burden, existing health systems, and reaction to self-administered treatment, this study will develop and adapt a model for community engagement toward malaria elimination that is cost-effective and fits within the existing health system.TRIAL REGISTRATION: Clinical trials.gov, NCT02878200 . Registered on 25 August 2016.

KW - Antimalarials/administration & dosage

KW - Community Health Services

KW - Data Analysis

KW - Data Collection

KW - Humans

KW - Malaria, Falciparum/drug therapy

KW - Randomized Controlled Trials as Topic

KW - Self Administration

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DO - 10.1186/s13063-018-2506-x

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ER -

Reactive community-based self-administered treatment against residual malaria transmission: study protocol for a randomized controlled trial

Abstract

UN SDGs

Keywords

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