Targeting DNA methyltransferases in non-small-cell lung cancer

Minnatallah Al-Yozbaki; Ibtissam Jabre; Naeem Syed; Cornelia Wilson

doi:10.1016/j.semcancer.2021.01.005

Targeting DNA methyltransferases in non-small-cell lung cancer

Minnatallah Al-Yozbaki
, Ibtissam Jabre
, Naeem Syed
, Cornelia Wilson

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Despite the advances in treatment using chemotherapy or targeted therapies, due to static survival rates, non-small cell lung cancer (NSCLC) is the major cause of cancer-related deaths worldwide. Epigenetic-based therapies have been developed for NSCLC by targeting DNA methyltransferases (DNMTs) and histone-modifying enzymes. However, treatment using single epigenetic agents on solid tumours has been inadequate; whereas, treatment with a combination of DNMTs inhibitors with chemotherapy and immunotherapy has shown great promise. Dietary sources of phytochemicals could also inhibit DNMTs and cancer stem cells, representing a novel and promising way to prevent and treat cancer. Herein, we will discuss the different DNMTs, DNA methylation profiling in NSCLC as well as current demethylating agents in ongoing clinical trials. Therefore, providing a concise overview of future developments in the field of epigenetic therapy in NSCLC.

Original language	English
Journal	Seminars in Cancer Biology
DOIs	https://doi.org/10.1016/j.semcancer.2021.01.005
Publication status	Published - 21 Jan 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

DNA methylation
DNA methyltransferases
Demethylating agents
Dietary phytochemicals
Non-small cell lung cancer

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title = "Targeting DNA methyltransferases in non-small-cell lung cancer",

abstract = "Despite the advances in treatment using chemotherapy or targeted therapies, due to static survival rates, non-small cell lung cancer (NSCLC) is the major cause of cancer-related deaths worldwide. Epigenetic-based therapies have been developed for NSCLC by targeting DNA methyltransferases (DNMTs) and histone-modifying enzymes. However, treatment using single epigenetic agents on solid tumours has been inadequate; whereas, treatment with a combination of DNMTs inhibitors with chemotherapy and immunotherapy has shown great promise. Dietary sources of phytochemicals could also inhibit DNMTs and cancer stem cells, representing a novel and promising way to prevent and treat cancer. Herein, we will discuss the different DNMTs, DNA methylation profiling in NSCLC as well as current demethylating agents in ongoing clinical trials. Therefore, providing a concise overview of future developments in the field of epigenetic therapy in NSCLC.",

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author = "Minnatallah Al-Yozbaki and Ibtissam Jabre and Naeem Syed and Cornelia Wilson",

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doi = "10.1016/j.semcancer.2021.01.005",

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T1 - Targeting DNA methyltransferases in non-small-cell lung cancer

AU - Al-Yozbaki, Minnatallah

AU - Jabre, Ibtissam

AU - Syed, Naeem

AU - Wilson, Cornelia

PY - 2021/1/21

Y1 - 2021/1/21

N2 - Despite the advances in treatment using chemotherapy or targeted therapies, due to static survival rates, non-small cell lung cancer (NSCLC) is the major cause of cancer-related deaths worldwide. Epigenetic-based therapies have been developed for NSCLC by targeting DNA methyltransferases (DNMTs) and histone-modifying enzymes. However, treatment using single epigenetic agents on solid tumours has been inadequate; whereas, treatment with a combination of DNMTs inhibitors with chemotherapy and immunotherapy has shown great promise. Dietary sources of phytochemicals could also inhibit DNMTs and cancer stem cells, representing a novel and promising way to prevent and treat cancer. Herein, we will discuss the different DNMTs, DNA methylation profiling in NSCLC as well as current demethylating agents in ongoing clinical trials. Therefore, providing a concise overview of future developments in the field of epigenetic therapy in NSCLC.

AB - Despite the advances in treatment using chemotherapy or targeted therapies, due to static survival rates, non-small cell lung cancer (NSCLC) is the major cause of cancer-related deaths worldwide. Epigenetic-based therapies have been developed for NSCLC by targeting DNA methyltransferases (DNMTs) and histone-modifying enzymes. However, treatment using single epigenetic agents on solid tumours has been inadequate; whereas, treatment with a combination of DNMTs inhibitors with chemotherapy and immunotherapy has shown great promise. Dietary sources of phytochemicals could also inhibit DNMTs and cancer stem cells, representing a novel and promising way to prevent and treat cancer. Herein, we will discuss the different DNMTs, DNA methylation profiling in NSCLC as well as current demethylating agents in ongoing clinical trials. Therefore, providing a concise overview of future developments in the field of epigenetic therapy in NSCLC.

KW - DNA methylation

KW - DNA methyltransferases

KW - Demethylating agents

KW - Dietary phytochemicals

KW - Non-small cell lung cancer

U2 - 10.1016/j.semcancer.2021.01.005

DO - 10.1016/j.semcancer.2021.01.005

M3 - Article

SN - 1044-579X

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

ER -

Targeting DNA methyltransferases in non-small-cell lung cancer

Abstract

UN SDGs

Keywords

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